1. Quick substitutions
You are forced to use 6 players for your substitutions. For example, you can't set to have 2 different subs for your striker, and choose between the options during the game (you might want to change him for a tall one or a quick one, depending on the outcome of the game). Also, when playing the game, I was offered to do a quick sub only once, in 83rd minute, and I could only perform one, not 2 or 3.
2. Opposition AI is still dumb
I was playing Juve - Man Utd game, and obviously, Man Utd are so much better than Juve that they have to go All out on attack in 75th min when the score is 0-0. Career mode gonna suck yet again. The All out on attack / Park the bus are the worst things, as they are applied incorrectly and unrealistically.