I played 4222 and although it was good going forward, i kept getting caught on the counter. I decided to switch up my team and build for a 532. I sold my First Owner Messi and picked up 86 R.Carlos (LWB) and 87 Lahm (playing RWB on 7 Chem).
It's beautiful. I feel pretty secure defensively and going forward, it just suits my style of fast 1-2s, switching the ball from one side to another. Both full backs are on 'Join the attack' They provide a great outlet, the opponent doesn't know whether to go to them or stick with the LCM/RCM.
I really like the balance, if you are struggling, i suggest giving it a go.