Changing formation in game, does it work with every formation?

368 posts Sunday League Hero
I see most of the pro players change from 4321 to 41212(2). I don't know if the positions are similar like the LF play as ST or it's just because it's easy to make a hybrid

If I start with the 451 and change to 4321 in game would it be ok? I know that in theory it would, but I don't see any good players do it
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